Victor Osimhen, experienced his biggest defeat since joining Napoli three years ago.

The star Forward was in action ad the Serie A Champions suffered a humiliating 4-0 loss to Frosinone on Tuesday, resulting in their unexpected exit from the Coppa Italia.

Osimhen, who recently scored against Braga and Cagliari, initially started the game on the bench.

Coach Walter Mazzarri opted for Giamoco Raspadori and Giovanni Simeone in the attack. However, facing a 0-0 deadlock and aiming to avoid extra time, Osimhen was brought in along with Kvicha Kvaratskhelia just past the hour mark.

Unfortunately for Napoli, Frosinone seized the lead moments after Osimhen’s entry, as Enzo Barrenechea capitalized on a free header from six yards.

The situation worsened when Frosinone doubled their advantage in a similar fashion, intercepting a back-pass from Giovanni Di Lorenzo.

The misery continued for Napoli as Di Lorenzo’s foul on Francesco Gelli led to a penalty, expertly converted by Cheddira, who is on loan from Napoli.

In the dying moments of the game, Abdou Harroui sealed Frosinone’s historic victory with a one-on-one goal against Pierluigi Gollini.​

This defeat marks a historic moment for Frosinone, as they not only secured their first-ever victory against Napoli but also advanced to the Coppa Italia quarter-final, where they are set to face Juventus or Salernitana.

The crowd’s deafening jeers underscored Napoli’s unexpected downfall in the tournament.